Professor at University of Rome Tor Vergata, Italy
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🎓 Academic and Professional Background
Magda Gioia is an Associate Professor of Biochemistry at the University of Rome Tor Vergata, with a robust academic foundation in biochemistry and molecular biology. She earned her Ph.D. in Biochemistry and Molecular Biology from the University of Rome ‘Tor Vergata’ in 2005 and completed her Master’s in Biological Sciences at Roma Tre University in 2000. Her professional journey is marked by tenure-track and professorial roles, culminating in a Full Professor qualification in Italy in 2022.
Her research has significantly advanced biochemical and enzymatic processes, particularly through the DEGRADOMICs: CLIP-TAILs project, which introduced groundbreaking proteomic methods for identifying metalloprotease substrates. Currently, her work bridges structural biology and cellular biology, focusing on osteogenesis under pathological stimuli, bone resorption in microgravity, and mechanobiology in cancer cells.
🔬 Areas of Research
Magda’s research spans the dynamic fields of biochemistry, cell biochemistry, and mechanobiology. Her innovative contributions explore the biochemical mechanisms underlying cancer metastasis, osteogenesis, and microgravity-induced bone resorption.
🌍 Contributions to Research and Innovation
Motivated by the aggressive nature of osteosarcoma (OS) and the limitations of existing therapies, Magda’s research investigates how biophysical forces influence OS cell behavior. Through cutting-edge technologies like uniaxial stretch technology, advanced microscopy, and molecular assays, her studies have revealed:
Nuclear size alterations and changes in the nuclear-to-cytoplasmic ratio in OS cells under mechanical stimulation.
Activation of mechanosensitive (MS) channels, resulting in reactive oxygen species (ROS) accumulation, Src modulation, and histone H3 acetylation.
Impacts on cell motility, adhesion, and drug resistance, all critical factors in tumor progression.
đź“ś Professional Memberships
Magda is an active member of various prestigious professional organizations and societies dedicated to advancing biochemical research and innovation.
Publications Top Notedđź“ť
GsMTx-4 venom toxin antagonizes biophysical modulation of metastatic traits in human osteosarcoma cells
Authors: Buglione, A.; Alloisio, G.; Ciaccio, C.; Cricenti, A.; Gioia, M.
Journal: European Journal of Cell Biology
Year: 2025
Multi-Anticancer Activities of Phytoestrogens in Human Osteosarcoma
Authors: Cimmino, A.; Fasciglione, G.F.; Gioia, M.; Marini, S.; Ciaccio, C.
Journal: International Journal of Molecular Sciences
Year: 2023
Cyclic Stretch-Induced Mechanical Stress Applied at 1 Hz Frequency Can Alter the Metastatic Potential Properties of SAOS-2 Osteosarcoma Cells
Authors: Alloisio, G.; Rodriguez, D.B.; Luce, M.; Cricenti, A.; Gioia, M.
Journal: International Journal of Molecular Sciences
Year: 2023
Mechano-induced cell metabolism disrupts the oxidative stress homeostasis of SAOS-2 osteosarcoma cells
Authors: Fanelli, G.; Alloisio, G.; Lelli, V.; Rinalducci, S.; Gioia, M.
Journal: Frontiers in Molecular Biosciences
Year: 2023
Saliva Analysis of pH and Antioxidant Capacity in Adult Obstructive Sleep Apnea Patients
Authors: Venza, N.; Alloisio, G.; Gioia, M.; Danesi, C.; LaganĂ , G.
Journal: International Journal of Environmental Research and Public Health
Year: 2022