Doctorate at Dalian University of Technology, China
Professional Profile
Orcid
🎓 Academic and Professional Background
Shanshan Lu earned her degree from the Brain Science Center, Beijing Institute of Basic Medical Sciences, where she trained under the esteemed guidance of Yizheng Wang. Her work focuses on disease mechanisms related to ischemic stroke and the development of effective drug targets. Leveraging molecular docking techniques, she investigates interactions between small molecules and proteins, providing novel insights into disease progression and therapeutic strategies.
🔬Research Interests & ContributionsÂ
Dr. Lu’s research focuses on disease mechanisms related to ischemic stroke, aiming to explore new drug targets based on the underlying pathogenesis. One of her notable contributions is in the area of molecular docking, where she works to screen and predict interactions between small molecules and proteins and investigates how signaling pathways play a role in the development of diseases.
Her work also includes groundbreaking findings related to cortisol and its effects on sonic hedgehog (Shh)/SMO-mediated proliferation of lung fibroblasts. Dr. Lu showed how cortisol competes with cholesterol to bind the cysteine-rich domain (CRD) in SMO, ultimately inhibiting Shh/SMO signaling essential for cell proliferation. Her studies on Smoa/a(L116A) mice provided key insights into lung development, revealing abnormalities such as over-proliferation of fibroblasts and a reduction in surfactant proteins.
Publications Top Notedđź“ť
Cortisol regulates neonatal lung development via Smoothened
Authors: Shanshan Lu, Yifei Chen, Jiawen Song, Liangliang Ren, Jun Du, Donglai Shen, Jiayin Peng, Yao Yin, Xia Li, Yuqing Wang et al.
Journal: Respiratory Research
Year: 2025
PKCα phosphorylation of GLT-1 at Ser562/563 induces glutamate excitotoxicity in ischemia in mice
Authors: Yuqing Wang, Jun Du, Shanshan Lu, Xia Li, Yifei Chen, Chao Yuan, Sheng-Tao Hou, Yizheng Wang
Journal: Signal Transduction and Targeted Therapy
Year: 2022
Smoothened is a therapeutic target for reducing glutamate toxicity in ischemic stroke
Authors: Yuqing Wang, Shanshan Lu, Yifei Chen, Liang Li, Xia Li, Zhongwei Qu, Junbo Huang, Liu Fan, Chao Yuan, Nan Song et al.
Journal: Science Translational Medicine
Year: 2021
Sonic hedgehog induces GLT-1 degradation via PKC delta to suppress its transporter activities
Authors: Yuqing Wang, Shanshan Lu, Zhongwei Qu, Lin Wu, Yizheng Wang
Journal: Neuroscience
Year: 2017