Doctorate at Department of Organic Chemistry, University of Yaoundé 1, Cameroon
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đEducation Background
Dr. Nicolas has a robust educational foundation in Organic Chemistry and Applied Chemistry. She completed her Ph.D. at the University of YaoundĂ© I, Cameroon, specializing in biflavonoids and other chemical constituents from Ochna schweinfurthiana and Ochna rhizomatosa. Her research focused on isolation, structure elucidation, and bioassays of these compounds. She holds a Masterâs Degree and Masterâs I Degree from the University of Ngaoundere, Cameroon, and a Bachelorâs Degree in Applied Chemistry from the same institution. Additionally, Dr. Nicolas completed a DEUG in Applied Chemistry and has an Advanced Level in Sciences and Mathematics from B.G.S Buea, Cameroon.
đŹProfessional Skills
Dr. Messi Angelique Nicolas is an expert in chromatographic techniques such as Column, Flash, Reverse Phase, MPLC, HPLC, and Preparative TLC. She possesses strong knowledge in spectroscopic methods like NMR, IR, LC-MS, GC-MS, and HRESIMS. With extensive experience in project management and team leadership, she is skilled in reaction optimization and conformational analysis. Dr. Nicolas has a solid understanding of GLP (Good Laboratory Practice) and laboratory safety requirements. Her research also delves into the synthesis of bioactive compounds and their isolation from medicinal plants. She is fluent in both French and English, with excellent communication and interpersonal skills. Dr. Nicolas has also taught at the university level and is proficient in Microsoft Office tools, Chemdraw, and other relevant software.
đŹđĄResearch Areas
Dr. Nicolas’ research lies at the intersection of pharmaceutical and natural products chemistry. Her focus is on neuroinflammation, neuroprotective effects, anticancer, antimalarial, and anti-HIV/AIDS properties (especially against multiple-drug-resistant strains). She investigates the neurochemistry of purified compounds from higher plants and synthetic organic compounds. Her work aims to uncover novel therapeutic agents for a range of diseases and disorders.
đ±đŹResearch Interests
Her research interests include drug discovery from natural products, particularly flavonoids, biflavonoids, and bioguided isolation. Dr. Nicolas is dedicated to the synthesis of bioactive natural products from medicinal plants, developing bioassays for screening plant extracts and isolated compounds. She also applies advanced 1D and 2D NMR techniques in drug discovery and chemotaxonomy, advancing the field of natural product chemistry.
đđAcademic Awards & Fellowships
Dr. Messi Angelique Nicolas has been honored with several prestigious awards and fellowships throughout her career. Notably, she was selected for a Research Visit at the University of Free State, South Africa, from January to May 2023, where she furthered her research. In addition, Dr. Nicolas was awarded a Postdoctoral Research Fellowship at the University of Fribourg, Switzerland, during the 2020-2021 period, under the Young Researchers’ Fellowship program. This opportunity allowed her to collaborate on cutting-edge research and expand her academic expertise. Her dedication to scientific excellence is also recognized through the TWAS (The World Academy of Science) Fellowship, which provided financial support for her work in chemistry (UNESCO FR: 3240277733). Earlier in her career, Dr. Nicolas received a PhD Research Fellowship at the University of Free State, South Africa, from January to May 2015, which allowed her to complete significant portions of her doctoral research. These awards reflect her commitment to advancing the field of natural product chemistry and pharmaceutical research.
Publications Top Notedđ
Rhizomatoflavonoid D and Other Flavonoids from the Twigs of Ochna Rhizomatosa as a Potential Inhibitor of HIV-1
Authors: Messi, A.N., Tsakem, B., Akongwi, M., Ngo Mbing, J., Pegnyemb, D.E.
Journal: Chemistry Africa
Year: 2024
Biflavonoid Methylchamaejasmin and Khaya grandifoliola Extract Inhibit NLRP3 Inflammasome in THP-1 Cell Model of Neuroinflammation
Authors: Owona, B.A., Mary, A., Messi, A.N., Moundipa, P.F., Heneka, M.T.
Journal: Molecular Neurobiology
Year: 2024
In Vitro and In Silico Potential Inhibitory Effects of New Biflavonoids from Ochna Rhizomatosa on HIV-1 Integrase and Plasmodium falciparum
Authors: Messi, A.N., Bonnet, S.L., Owona, B.A., Pegnyemb, D.E., Bochet, C.G.
Journal: Pharmaceutics
Year: 2022
Phytochemical Study of Aqueous Extract of Ochna schweinfurthiana F. Hoffm Powder Bark and Evaluation of Their Anti-Inflammatory, Cytotoxic, and Genotoxic Properties
Authors: Djova, S.V., Nyegue, M.A., Messi, A.N., Afagnigni, A.D., Etoa, F.-X.
Journal: Evidence-based Complementary and Alternative Medicine
Year: 2019
Phenolic Compounds from the Roots of Ochna schweinfurthiana and Their Antioxidant and Antiplasmodial Activities
Authors: Messi, A.N., Ngo Mbing, J., Ndongo, J.T., Frédérich, M., Pegnyemb, D.E.
Journal: Phytochemistry Letters
Year: 2016