Mrs. Feifei Song | UNC-CH, China
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馃帗Academic and Professional Background
Feifei Song earned a Ph.D. from Wuhan University in China, where she specialized in liver cancer research. During this time, she published influential studies that unveiled the pivotal roles of microRNAs in liver cancer progression and identified novel therapeutic targets. Since 2019, she has served as a Postdoctoral Research Associate at UNC-CH, focusing on advancing CAR-T cell therapy for hematologic malignancies and expanding its application to solid tumors. Her innovative work includes systematically screening kinase inhibitors, identifying three that significantly preserve the stem-cell-like phenotype of CAR-T cells during manufacturing, which is poised to improve therapeutic outcomes.
馃敩Areas of Research
Feifei Song鈥檚 research lies at the intersection of cancer biology, immunotherapy, and CAR-T cell optimization. She is dedicated to investigating novel therapeutic targets for Hepatocellular Carcinoma (HCC), focusing on uncovering pathways and molecules that drive tumor development and progression. Her work also emphasizes advancing immunotherapy approaches to improve the effectiveness of treatments for various cancers, including solid tumors. Additionally, Feifei is committed to developing innovative strategies to optimize CAR-T cell manufacture and functionality, ensuring these engineered immune cells maintain their stem-cell-like phenotype and enhanced persistence during and after treatment.
Publications Top Noted馃摑
4-1BB-encoding CAR causes cell death via sequestration of the ubiquitin-modifying enzyme A20
Authors: Dou, Z.; Bonacci, T.R.; Shou, P.; ...; Dotti, G.; Zhou, X.
Journal: Cellular and Molecular Immunology
Year: 2024
Implantable CAR T cell factories enhance solid tumor treatment
Authors: Pandit, S.; Agarwalla, P.; Song, F.; ...; Dotti, G.; Brudno, Y.
Journal: Biomaterials
Year: 2024
Preclinical evaluation of B7-H3-specific chimeric antigen receptor T cells for the treatment of acute myeloid leukemia
Authors: Lichtman, E.I.; Du, H.; Shou, P.; ...; Savoldo, B.; Dotti, G.
Journal: Clinical Cancer Research
Year: 2021