Doctorate at Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital | China
Dr. Lijun Yan is an accomplished physician and researcher specializing in geriatric gastroenterology. Currently serving as an Attending Physician at the Department of Geriatric Gastroenterology at the Affiliated Hospital of Nanjing Medical University, Nanjing, China, Dr. Yan combines clinical practice with cutting-edge research, focusing on novel therapeutic approaches in gastroenterology, oncology, and nanomaterials.
Professional Profile
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🎓 Education and Academic Background
Dr. Lijun Yan (严丽军) holds an impressive academic record in medicine, reflecting her dedication to advancing medical science. She earned her PhD in Gerontology from Nanjing Medical University (2019–2022), where she explored age-related diseases and their management. Her postgraduate journey began with a Master of Medicine in Gastroenterology at the same institution (2013–2016), highlighting her specialization in digestive system disorders. Prior to that, she completed her Bachelor of Medicine in Clinical Medicine at Soochow University (2008–2013), laying the foundation for her clinical expertise.
🔬 Research Activities and Funded Grants
Dr. Lijun Yan has led and contributed to groundbreaking research projects in cancer biology and nanomedicine, showcasing her innovation and leadership. Her notable funded research includes exploring the mechanism of betulinic acid in alleviating liver injury through the Nrf-2/HO-1/NF-κB signaling pathway (2017–2019, Health Commission, Nantong). She investigated LncRNAn336928-mediated SPP1 expression in gastrointestinal and pancreatic neuroendocrine tumors (2019–2021, Health Commission, Jiangsu Province). Additionally, she developed a comprehensive diagnosis and treatment system for digestive system neuroendocrine neoplasms, utilizing cutting-edge techniques such as molecular detection, endoscopy, imaging, and nanotherapy (2020–2022, Science and Technology Office, Jiangsu Province). Dr. Yan also delved into VEGF-mediated neovascularization, employing controlled-release octreopeptide/baicalein nanomicelles for treating pancreatic neuroendocrine tumors (2020–2022, National Natural Science Foundation). Most recently, she is exploring tyrosine kinase reducers synthesized from PROTAC in treating pancreatic neuroendocrine tumors (2022–2024, as Project Leader). Her dedication to advancing medical science through innovative research is both inspiring and impactful.
🔎 Research Interests
Dr. Yan’s research spans the cutting-edge intersections of modern science and clinical applications, reflecting her passion for innovation. Her key areas of interest include Nanomaterials and Medicine, focusing on harnessing nanotechnology for therapeutic breakthroughs. She is also deeply engaged in Small Molecule Drugs and Biology, exploring their potential in disease treatment. Dr. Yan applies her expertise in Bioinformatics and Genomics to decipher the genetic underpinnings of health and disease. Furthermore, her commitment to Cancer Biology drives her to uncover mechanisms and develop strategies for cancer treatment, reinforcing her role as a leader in the field.
🧪 Laboratory Skills
Dr. Yan is highly skilled in a wide range of laboratory techniques, underscoring her hands-on expertise in medical research. She excels in Chemical Synthesis, with proficiency in creating small molecule drugs and designing photosensitive nanomaterials. Her expertise in Molecular Biology Techniques, such as quantitative real-time PCR, Western blotting, and immunohistochemistry, further highlights her technical mastery. Dr. Yan is adept in Microscopy, including light microscopy, fluorescence microscopy, and scanning electron microscopy, which she utilizes for detailed analysis. She also specializes in Cell Biology, with experience in cell culture, maintaining cell lines, and conducting mouse models for studying cancer and inflammation. Additionally, her knowledge of Bioinformatics and Medical Statistics enables her to analyze and interpret complex biological data effectively.
🌟 Professional Highlights
Dr. Lijun Yan’s pioneering contributions to geriatric gastroenterology and cancer research have significantly advanced medical knowledge and therapeutic approaches. Her innovative work, particularly in nanomedicine and small molecule drug development, has established her as a leading figure in the field. Through her dedication to both research and clinical practice, she continues to enhance diagnostic and therapeutic options while inspiring the next generation of medical researchers.
Publications Top Notedđź“š
A Hypoxia Signature for Predicting Prognosis and Tumor Immune Microenvironment in Adrenocortical Carcinoma
Authors: Xi Chen, Lijun Yan, Yu Lu, Feng Jiang, Ni Zeng, Shufang Yang, Xianghua Ma, Gagan Chhabra
Journal: Journal of Oncology
Year: 2021
Identification of a Ferroptosis-Related Signature Associated with Prognosis and Immune Infiltration in Adrenocortical Carcinoma
Authors: Xi Chen, Lijun Yan, Feng Jiang, Yu Lu, Ni Zeng, Shufang Yang, Xianghua Ma, Giuseppe Reimondo
Journal: International Journal of Endocrinology
Year: 2021
Ganoderic acid A against cyclophosphamide-induced hepatic toxicity in mice
Authors: Xu Lixin, Yan Lijun, Huang Songping
Journal: Journal of Biochemical and Molecular Toxicology
Year: 2019
Yi Guan Jian, a Traditional Chinese Herbal Medicine, Alleviates Carbon Tetrachloride-Induced Liver Injury
Authors: Xu Lixin, Gu Erli, Huang Songping, Zhu Yonggen, Wang Jianping, Yan Lijun
Journal: Evidence-based Complementary and Alternative Medicine
Year: 2019
Pilose antler peptide attenuates high-fat-diet-induced liver injury
Authors: Xu Lixin, Yan Lijun, Tao Weiwei
Journal: Toxicology Mechanisms and Methods
Year: 2018